See full publication list here
†Authors contributed equally ¶Corresponding authors
Selected works (co-)led by team members
Chen-Yang Su, Adriaan van der Graaf, Wenmin Zhang, Dong-Keun Jang, Susannah Selber-Hnatiw, Ta-Yu Yang, Guillaume Butler-Laporte, Kevin Y. H. Liang, Fumihiko Matsuda, Maria C. Constanzo, Noel P. Burtt, Jason Flannick, Sirui Zhou, Vincent Mooser, Tianyuan Lu¶, and Satoshi Yoshiji¶. Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets. Submitted.
Wenmin Zhang¶, Satoshi Yoshiji, Robert Sladek, Josée Dupuis¶, and Tianyuan Lu¶. Benchmarking Bayesian colocalization methods in validating Mendelian randomization-based target discoveries from circulating proteins for cardiometabolic diseases. Submitted.
Tianyuan Lu¶, Wenmin Zhang, Fergus W. Hamilton, Guillaume Butler-Laporte, Nicholas J. Timpson, George Davey Smith, and J. Brent Richards¶. Challenges to the independence assumption in Mendelian randomization due to sample selection and complex methods. Submitted.
Tianyuan Lu¶, Wenmin Zhang, Cassiane Robinson-Cohen, Corinne D. Engelman, Qiongshi Lu, Ian H. de Boer, Lei Sun, and Andrew D. Paterson. Improved characterization of gene-environment interactions for vitamin D through variance quantitative trait loci. Submitted.
Tianyuan Lu¶, Despoina Manousaki, Lei Sun, and Andrew D. Paterson¶. Integrative proteogenomic analyses provide novel interpretations of type 1 diabetes risk loci through circulating proteins. Submitted.
Tianyuan Lu¶ and Andrew D. Paterson¶. Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study. Submitted.
Wenmin Zhang, Chen-Yang Su, Satoshi Yoshiji, and Tianyuan Lu¶. MR Corge: Sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures. Bioinformatics 2024. Link to publication
Tianyuan Lu¶, Yiheng Chen, Satoshi Yoshiji, Yann Ilboudo, Vincenzo Forgetta, Sirui Zhou, and Celia M. T. Greenwood¶. Circulating metabolite abundances associated with risks of psychiatric disorders: a Mendelian randomization study. Biological Psychiatry 2024. Link to publication
Tianyuan Lu¶, Vincenzo Forgetta, Sirui Zhou, J Brent Richards, and Celia M. T. Greenwood¶. Identifying rare genetic determinants for improved polygenic risk prediction of bone mineral density and fracture risk. Journal of Bone and Mineral Research 2023. Link to publication
Lady Davis Institute Paper of the Month (December 2023)
Tianyuan Lu¶, Tomoko Nakanishi, Satoshi Yoshiji, Guillaume Butler-Laporte, Celia M. T. Greenwood, and J. Brent Richards¶. Dose-dependent association of alcohol consumption with obesity and type 2 diabetes: observational and Mendelian randomization analyses. The Journal of Clinical Endocrinology & Metabolism 2023. Link to publication
Endocrine Society News Release (June 2023)
Tianyuan Lu¶, Vincenzo Forgetta, J. Brent Richards, and Celia M. T. Greenwood¶. Genetic determinants of polygenic prediction accuracy within a population. Genetics 2022. Link to publication
Tianyuan Lu, Vincenzo Forgetta, Celia M. T. Greenwood, Sirui Zhou, and J. Brent Richards¶. Circulating proteins influencing psychiatric disease: A Mendelian randomization study. Biological Psychiatry 2022. Link to publication
Prix Relève Étoile Jacques-Genest / Best Publication Award – Health Sciences of Québec (March 2023)
Tianyuan Lu¶, Vincenzo Forgetta, J. Brent Richards, and Celia M. T. Greenwood¶. Capturing additional genetic risk from family history for improved polygenic risk prediction. Communications Biology 2022. Link to publication
Tianyuan Lu, Vincenzo Forgetta, Celia M. T. Greenwood, and J. Brent Richards¶. Identifying causes of fracture beyond bone mineral density: Evidence from human genetics. Journal of Bone and Mineral Research 2022. Link to publication
Tianyuan Lu, Vincenzo Forgetta, J. Brent Richards, and Celia M. T. Greenwood¶. Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases. Genetics in Medicine 2022. Link to publication
Célia Escribe†, Tianyuan Lu†, Julyan Keller-Baruch, Vincenzo Forgetta, Bowei Xiao, J. Brent Richards, Sahir Bhatnagar, Karim Oualkacha and Celia M. T. Greenwood¶. Block coordinate descent algorithm improves variable selection and estimation in error-in-variables regression. Genetic Epidemiology 2021. Link to publication
Highlight of Issue (December 2021)
Tianyuan Lu, Andres Cardenas, Patrice Perron, Marie-France Hivert, Luigi Bouchard, and Celia M. T. Greenwood¶. Detecting cord blood cell type-specific epigenetic associations with gestational diabetes mellitus and early childhood growth. Clinical Epigenetics 2021. Link to publication
Tianyuan Lu, Vincenzo Forgetta, Haoyu Wu, John R. B. Perry, Ken K. Ong, Celia M. T. Greenwood, Nicholas J. Timpson, Despoina Manousaki, and J. Brent Richards¶. A polygenic risk score to predict future adult short stature among children. The Journal of Clinical Endocrinology & Metabolism 2021. Link to publication
Tianyuan Lu†, Vincenzo Forgetta†, Julyan Keller-Baruch, Maria Nethander, Derrick Bennett, Marie Forest, Sahir Bhatnagar, Robin G. Walters, Kuang Lin, Zhengming Chen, Liming Li, Magnus Karlsson, Dan Mellström, Eric Orwoll, Eugene V. McCloskey, John A. Kanis, William D. Leslie, Robert J. Clarke, Claes Ohlsson, Celia M. T. Greenwood, and J. Brent Richards¶. Improved prediction of fracture risk leveraging a genome-wide polygenic risk score. Genome Medicine 2021. Link to publication
Tianyuan Lu and Jessica C. Mar¶. Investigating transcriptome-wide sex dimorphism by multi-level analysis of single-cell RNA sequencing data in ten mouse cell types. Biology of Sex Differences 2020. Link to publication
Tianyuan Lu, Sirui Zhou, Haoyu Wu, Vincenzo Forgetta, Celia M. T. Greenwood, J. Brent Richards¶. Individuals with common diseases, but with a low polygenic risk score could be prioritized for rare variant screening. Genetics in Medicine 2020. Link to publication
Editor’s Featured Article (March 2021)
Tianyuan Lu, Vincenzo Forgetta, Oriana H. Y. Yu, Lauren Mokry, Madeline Gregory, George Thanassoulis, Celia M. T. Greenwood and J. Brent Richards¶. Genetic influences on coronary heart disease act on atherosclerosis in type 2 diabetes. Cardiovascular Diabetology 2020. Link to publication
Selected collaborative works
Jiacheng Miao, Yixuan Wu, Zhongxuan Sun, Xinran Miao, Tianyuan Lu, Jiwei Zhao, and Qiongshi Lu¶. Valid inference for machine learning-assisted GWAS. Nature Genetics 2024. Link to publication
Thomas R. Austin†, Maria Nethander†, Howard A. Fink†, Anna E. Törnqvist, Diana I. Jalal, Petra Buzkova, Joshua I. Barzilay, Laura Carbone, Maiken E. Gabrielsen, Louise Grahnemo, Tianyuan Lu, Kristian Hveem, Christian Jonasson, Jorge R. Kizer, Arnulf Langhammer, Kenneth J. Mukamal, Robert E. Gerszten, Bruce M. Psaty, John A. Robbins, Yan V. Sun, Anne Heidi Skogholt, John A. Kanis, Helena Johansson, Bjørn Olav Åsvold, Rodrigo J. Valderrabano, Jie Zheng, J. Brent Richards, Eivind Coward, and Claes Ohlsson¶. A protein-based risk score improves hip fracture prediction. Nature Aging 2024. Link to publication
Wenmin Zhang¶ ,Tianyuan Lu, Robert Sladek, Yue Li, Hamed S. Najafabadi, and Josée Dupuis¶. SharePro: an accurate and efficient genetic colocalization method accounting for multiple causal signals. Bioinformatics 2024. Link to publication
Guillaume Butler-Laporte¶, Joseph Farjoun, Tomoko Nakanishi, Tianyuan Lu, Erik Abner, Yiheng Chen, Michael Hulström, Andres Metspalu, Lili Milani, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Estonian Biobank Research Team, Satoshi Yoshiji, Yann Ilboudo, Kevin Y. H. Liang, Chen-Yang Su, Julian D. S. Willett, Tõnu Esko, Sirui Zhou, Vincenzo Forgetta, Daniel Taliun, and J. Brent Richards. HLA allele-calling using whole-exome sequencing identifies 129 novel associations in 11 autoimmune diseases: a multi-ancestry analysis in the UK Biobank. Communications Biology 2023. Link to publication
Maria Nethander†, Sofia Movérare-Skrtic†, Anders Kämpe, Eivind Coward, Ene Reimann, Louise Grahnemo, Éva Borbély, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E. Gabrielsen, Estonian Biobank Research Team, Reedik Mägi, Mari Hoff, Ulf H. Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Søren Brunak, DBDS Genomic Consortium, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Mäkitie, Kristian Hveem, J. Brent Richards, and Claes Ohlsson¶. An atlas of genetic determinants of forearm fracture. Nature Genetics 2023. Link to publication
Lei Sun¶, Zhong Wang, Tianyuan Lu, Teri A. Manolio, and Andrew D. Paterson¶. eXclusionarY: Ten years later, where are the sex chromosomes in GWAS? American Journal of Human Genetics 2023. Link to publication
Satoshi Yoshiji, Guillaume Butler-Laporte, Tianyuan Lu, Julian Daniel Sunday Willett, Chen-Yang Su, Tomoko Nakanishi, David Morrison, Yiheng Chen, Kevin Y. H. Liang, Michael Hultström, Yann Ilboudo, Zaman Afrasiabi, Shanshan Lan, Naomi Duggan, Chantal DeLuca, Mitra Vaezi, Chris Tselios, Xiaoqing Xue, Meriem Bouab, Fangyi Shi, Laetitia Laurent, Hans Markus Münter, Marc Afilalo, Jonathan Afilalo, Vincent Mooser, Nicholas J. Timpson, Hugo Zeberg, Sirui Zhou, Vincenzo Forgetta, Yossi Farjoun, and J. Brent Richards¶. Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity. Nature Metabolism 2023. Link to publication
Yiheng Chen, Tianyuan Lu, Ulrika Pettersson-Kymmer, Isobel D. Stewart, Guillaume Butler-Laporte, Tomoko Nakanishi, Agustin Cerani, Kevin Y. H. Liang, Satoshi Yoshiji, Julian Daniel Sunday Willett, Chen-Yang Su, Parminder Raina, Celia M. T. Greenwood, Yossi Farjoun, Vincenzo Forgetta, Claudia Langenberg, Sirui Zhou, Claes Ohlsson, and J. Brent Richards¶. Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nature Genetics 2023. Link to publication
Sahir Bhatnagar¶, Tianyuan Lu, Amanda Lovato, David L. Olds, Michael S. Kobor, Michael J. Meaney, Yi Yang and Celia M. T. Greenwood. A sparse additive model for high-dimensional interactions with an exposure variable. Computational Statistics & Data Analysis 2022. Link to publication
Ashot S. Harutyunyan†, Haifen Chen†, Tianyuan Lu, Cynthia Horth, Hamid Nikbakht, Brian Krug, Caterina Russo, Eric Bareke, Dylan M. Marchione, Mariel Coradin, Benjamin A. Garcia, Nada Jabado¶ and Jacek Majewski¶. H3K27M in gliomas causes a one-step decrease in H3K27 methylation and reduced spreading within the constraints of H3K36 methylation. Cell Reports 2020. Link to publication
Sahir Bhatnagar¶, Yi Yang, Tianyuan Lu, Erwin Schurr, J.C. Loredo-Osti, Marie Forest, Karim Oualkacha and Celia M. T. Greenwood. Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models. PLOS Genetics 2020. Link to publication